Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for FREE ACCESS to this landmark database

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Clinical Pediatrics
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0009922808323907v1
48/2/135    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Koul, P. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koul, P. B.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*UREA
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Diabetic Ketoacidosis: A Current Appraisal of Pathophysiology and Management

Pulin B. Koul, MB, MD

Division of Pediatric Critical Care Medicine, Department of Pediatrics, College of Medicine, University of Florida, Jacksonville, Florida, pulin.koul{at}jax.ufl.edu

Diabetic ketoacidosis (DKA) is a frequent abnormal metabolic entity seen in high-dependency units such as critical care units and in the emergency department. Having an understanding of its pathophysiology, a consequence of absent to low insulin levels, delineates the clinical presentation. Most clinical features are caused by hyperglycemia and acidosis, including weight loss. The newer management modalities are discussed that include the need for intensive laboratory workup, meticulous monitoring of the insulin, and fluid management. Among the complications, cerebral edema (CE) is the most dreaded, albeit with low incidence. The new insights into its pathophysiology and management are outlined, and a timeline for management of DKA is proposed.

Key Words: DKA • pathophysiology • cerebral edema • management • serum osmolality

This version was published on March 1, 2009

Clinical Pediatrics, Vol. 48, No. 2, 135-144 (2009)
DOI: 10.1177/0009922808323907
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?