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0009922807306056v1
47/2/176    most recent
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First published on September 14, 2007, doi:10.1177/0009922807306056

Clinical Pediatrics 2008;47:176.

A more recent version of this article appeared on March 1, 2008


Article

Occult Methicillin-Resistant Staphylococcus aureus Abscesses in 2 Pediatric Patients

Henry M. Feder Jr, MD*

University of Connecticut Health Center

* To whom correspondence should be addressed. E-mail: feder{at}nso2.uchc.edu.


   Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) infections have become more common over the last decade. Recently, severe MRSA infections including necrotizing pneumonia, purpura fulminans, and rapidly progressive skin abscesses have been reported. These severe infections frequently have been associated with the virulence factor Panton-Valentine leukocidin (PVL). Two unusual cases of occult deep tissue abscesses in children who had family members with a history of severe MRSA skin abscesses are presented in this article. Both children initially presented with fever without a focus. Deep tissue MRSA (PVL positive) abscesses evolved. Empiric antibiotic therapy for MRSA should be considered for infants and children who are hospitalized with occult fever and who have a family member with a history of MRSA infection.
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