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Bleeding After Circumcision in a Newborn Receiving Sildenafil

Children's Hospital & Research Center, Oakland, Calfornia, dgamboa{at}mail.cho.org

Daniel Robbins, MD

Lamorinda Pediatrics, Lafayette, California

Ziad Saba, MD

Department of Cardiology, Children's Hospital & Research Center, Oakland, California

This report describes a case of bleeding as a complication of circumcision in a 2-week-old infant being treated with sildenafil for persistent pulmonary hypertension of the newborn. The vasodilatory effects of sildenafil on the penile vasculature may have contributed to the postoperative bleeding in this patient.

Key Words: persistent pulmonary hypertension of the newborn • sildenafil • pulmonary vascular resistance • phosphodiesterase type 5 • circumcision

References

• Lakshminrusimha S., Steinhorn RH Pulmonary vascular biology during neonatal transition. Clin Perinatol. 1999;26:601-619.[Web of Science][Medline] [Order article via Infotrieve]
• Fox WW, Gewitz MG, Sinwiddie R., et al. Pulmonary hypertension in the perinatal aspiration syndromes. Pediatrics. 1977;59:205-211.[Abstract/Free Full Text]
• Konduri GG New approaches for persistent pulmonary hypertension of the newborn. Clin Perinatol. 2004;31: 591-611.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Walsh-Sukys MC, Tyson JE, Wright LL, et al. Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes. Pediatrics. 2000;105:14-20.[Abstract/Free Full Text]
• The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med. 1997;336:597-604.[Abstract/Free Full Text]
• Shekerdemian LS, Ravn HB, Penny DJ Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. Am J Respir Crit Care Med. 2002;165:1098-1102.[Abstract/Free Full Text]
• Sastry BK, Narasimhan C., Reddy NK, Raju BS Clinical efficacy of sildenafil in primary pulmonary hypertension: A randomized, placebo-controlled, double-blind, crossover study. J Am Coll Cardiol. 2004;43:1149-1532.[Abstract/Free Full Text]
• Michelakis E., Tymchak W., Lien D., et al. Oral Sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: Comparison with inhaled nitric oxide. Circulation. 2002;105:2398-2403.[Abstract/Free Full Text]
• Turko IV, Ballard SA, Francis SH, Corbin JD Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds. Mol Pharmacol. 1999;56:124-130.[Abstract/Free Full Text]
• Michelakis E., Tymchak W., Archer S. Sildenafil: From the bench to the bedside. CMAJ. 2000;163:1171-1175.[Abstract/Free Full Text]
• Abrams D., Schulze-Neick I., Magee AG Sildenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension. Heart. 2000;84:e4.[CrossRef][Medline] [Order article via Infotrieve]
• Carroll WD, Dhillon R. Sildenafil as a treatment for pulmonary hypertension. Arch Dis Child. 2003;88: 827-828.[Abstract/Free Full Text]
• Baquero H., Soliz A., Neira F., et al. Oral sildenafil in infants with persistent pulmonary hypertension of the newborn: A pilot randomized blinded study. Pediatrics. 2006;117:1077-1083.[Abstract/Free Full Text]

This version was published on December 1, 2007

Clinical Pediatrics, Vol. 46, No. 9, 842-843 (2007)
DOI: 10.1177/0009922807303546


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gamboa, D. Articles by Saba, Z. Search for Related Content PubMed PubMed Citation Articles by Gamboa, D. Articles by Saba, Z. Social Bookmarking                         What's this?