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Metastatic Medullary Thyroid Cancer in a Pediatric Patient with MEN 2B: Emphasis on the Need for Early Recognition of Extrathyroidal Clinical Findings Associated with MEN 2B

Divisions of Pediatric Endocrinology

William W. Shockley, MD

Divisions of Otolaryngology/Head/Neck Surgery

John D. Wright, MD

Divisions of Ophthalmology

Lisa Susswein, MS, CGC

Divisions of Genetics

Jim Evans, MD, PhD

Divisions of Genetics

William K. Funkhouser, MD, PhD

Divisions of Pathology, University of North Carolina, Chapel Hill, NC.

Karen J. Loechner, MD, PhD

Divisions of Pediatric Endocrinology

References

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• Eng C, Mulligan LM. Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumors, and Hirschprung disease. Hum Mutat. 1997;9:97-109.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Gharib H, McConahey WM, Tiegs RD, et al. Medullary thyroid carcinoma: clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970. Mayo Clin Proc. 1970;67:934-940.
• Leboulleux S, Travagli JP, Caillou B, et al. Medullary thyroid carcinoma as part of a multiple endocrine neoplasia type 2B syndrome. Cancer. 2002; 94:44-50.[Medline] [Order article via Infotrieve]
• Skinner MA, De Benedetti MK, Moley JF, et al. Medullary thyroid carcinoma in children with multiple endocrine neoplasia types 2A and 2B. J Pediatr Surg. 1996;31:177-182.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Braukhoff M, Gimm O, Weiss CL, et al. Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation: clinical manifestation and course in early and late onset disease. World J Surg. 2004;12:1305-1311.
• Torre M, Martucciello G, Ceccherini I, et al. Diagnostic and therapeutic approach to multiple endocrine neoplasia type 2B in pediatric patients. Pediatr Surg Int. 2002;18:378-383.[Medline] [Order article via Infotrieve]
• Yukihiko M, Minako K, Masakazu Y, et al. Multiple endocrine neoplasia 2B with glaucoma associated codon 918 mutation of the proto-oncogene. Acta Ophthalmol Scand. 1998;76:114-116.[Medline] [Order article via Infotrieve]
• Koh LK, Francis IC, Kappagoda MB, et al. Multiple endocrine neoplasia type two B. A case report with light and electron microscopic and immunohistochemical correlation. Aust N Z J Ophthalmol. 1995;4:343-350.

Clinical Pediatrics, Vol. 45, No. 5, 463-467 (2006)
DOI: 10.1177/0009922806289625


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This Article Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Barrows, F. P. Articles by Loechner, K. J. Search for Related Content PubMed PubMed Citation Articles by Barrows, F. P. Articles by Loechner, K. J. Pubmed/NCBI databases Medline Plus Health Information Eye Cancer Thyroid Cancer Social Bookmarking                         What's this?