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Clinical Pediatrics
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Cerebral Gigantism

Triad of Findings Helpful in Diagnosis

John W. Mace

Department of Pediatrics, Naval Hospital, San Diego, Calif

Ronald W. Gotlin

Department of Pediatrics, University of Colorado School of Medicine; previously on active duty, Naval Hospital, San Diego, Calif. 92134

Four cases of cerebral gigantism are reported, and their historical, phys ical and investigative findings are compared with those of other re ported cases. The triad of a period of rapid growth, advanced bone age and absence of precocious sexual development is characteristic of this syndrome and is seen rarely in other conditions. Extensive growth hormone and other pertinent assays, including circadian studies, failed to demonstrate any excess of endocrine secretions.

Clinical Pediatrics, Vol. 9, No. 11, 662-667 (1970)
DOI: 10.1177/000992287000901112
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