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Clinical Pediatrics
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The Synacthen Test of Adrenal Cortical Function in Children

A.G.F. Davidson

Hospital for Sick Children, Great Ormond Street, London, England

Carden Johnston

Hospital for Sick Children, Great Ormond Street, London, England, Hospital for Sick Children, Great Ormond Street, London, England

Adrenal cortical function was assessed in a dozen children by measurement of plasma cortisol rise after a single injection of the synthetic polypeptide Synacthen (ß1-24 cor ticotropin), and by measurement of urinary 17 hydroxycorticosteroid response to a three- day stimulation with ACTH.

Statistically significant correlation between the results of these two tests indicates that the Synacthen test is a valid and useful ap proach to appraising adrenal cortical funç tion in children.

The Synacthen test possesses a number of advantages over the ACTH test—the test substance is purer, the results are obtained much more quickly, and the risk of ana phylactic shock is eliminated.

Clinical Pediatrics, Vol. 7, No. 10, 626-629 (1968)
DOI: 10.1177/000992286800701017
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