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Clinical Pediatrics, Vol. 5, No. 8, 502-509 (1966)
DOI: 10.1177/000992286600500813

Long-Term Remissions in Childhood Acute Leukemia

Use of Infrequent Infusions of Methotrexate; Supportive Roles of Platelet Transfusions and Citrovorum Factor

Isaac Djerassi

Children's Hospital of Philadelphia and the Department of Pediatrics of the University of Pennsylvania, Philadelphia, Pennsylvania

Esshagh Abir

Children's Hospital of Philadelphia and the Department of Pediatrics of the University of Pennsylvania, Philadelphia, Pennsylvania

George L. Royer, JR

Children's Hospital of Philadelphia and the Department of Pediatrics of the University of Pennsylvania, Philadelphia, Pennsylvania

Carmen L. Treat

Children's Hospital of Philadelphia and the Department of Pediatrics of the University of Pennsylvania, Philadelphia, Pennsylvania

Here reported is the present status of studies exploring the possibility of large- scale destruction of leukemic cells by the use of infrequent but regular massive treatments with chemotherapeutic agents, aided by unusual supportive measures. Many noteworthy long remissions have been observed.


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