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Effect of Oral Sodium Cromoglycate in 2 Children With Food-Dependent Exercise-Induced Anaphylaxis (FDEIA)

Department of Pediatrics and Allergology, Sugimura Children's Medical Clinic, Chikugo, sugimura{at}kurume.ktarn.or.jp

Yoshifumi Tananari, MD

Department of Pediatric Cardiology, St Mary's Hospital, Kurume

Yukiko Ozaki, MD

Department of Pediatrics, Kurume University School of Medicine

Yasuki Maeno, MD

Department of Pediatrics, Kurume University Medical Center, Kurume Japan

Shinichi Ito, MD

Department of Pediatric Cardiology, St Mary's Hospital, Kurume

Yuno Yoshimoto, MD

Department of Pediatrics, Kurume University Medical Center, Kurume Japan

Keiko Kawano, MD

Department of Pediatrics, Kurume University Medical Center, Kurume Japan

Seiji Tanaka, MD

Department of Pediatrics, Kurume University Medical Center, Kurume Japan

Food-dependent exercise-induced anaphylaxis (FDEIA) was prevented from recurring in 2 children by sodium cromoglycate (SCG) before intake of the causative food. Case 1: A 14-year-old girl who had suffered recurrent symptoms of anaphylaxis when she exercised after lunch. Radioallergosorbent test (RAST) was 1.49 UA/mL for wheat. She was advised to take SCG before lunch. In 2007, she ate bread at lunchtime without taking SCG and developed anaphylaxis. After this, she always took SCG and did not develop anaphylaxis. Case 2: A 9-year-old boy who had recurrent symptoms of anaphylaxis when he exercised after lunch. RAST was 0.46 UA/mL for wheat. He started taking SCG before lunch. In June 2008, he forgot to take SCG and ate fu (a food made from wheat). He exercised after lunch and developed anaphylaxis. Since then, he has always taken SCG and has not developed anaphylaxis. Conclusion: Our findings suggest that SCG prevents FDEIA caused by wheat allergy.

Key Words: food-dependent exercise-induced anaphylaxis • sodium cromoglycate • children • wheat • gluten

This version was published on November 1, 2009

Clinical Pediatrics, Vol. 48, No. 9, 945-950 (2009)
DOI: 10.1177/0009922809337528


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