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Clinical Pediatrics
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The Association Between Iron Deficiency and Febrile Seizures in Childhood

Dawn S. Hartfield, MD, MPH

Department of Pediatrics, University of Alberta, Edmonton, Canada, dawn.hartfield{at}capitalhealth.ca

Jonathan Tan

Department of Pediatrics, University of Alberta, Edmonton, Canada

Jerome Y. Yager, MD

Department of Pediatrics, University of Alberta, Edmonton, Canada

Rhonda J. Rosychuk, PhD

Department of Pediatrics, University of Alberta, Edmonton, Canada

Don Spady, MD

Department of Pediatrics, University of Alberta, Edmonton, Canada

Christina Haines, MSc

Department of Pediatrics, University of Alberta, Edmonton, Canada

William R. Craig, MDCM

Department of Pediatrics, University of Alberta, Edmonton, Canada

Purpose. The purpose of this study was to determine the association between iron deficiency and febrile seizures in a large cohort of children aged 6 to 36 months. Methods. A retrospective case control study with 361 patients who presented with febrile seizures to the emergency department and 390 otherwise healthy controls who presented with a febrile illness to the emergency department were reviewed to determine iron status using the MCV, RDW, and hemoglobin. Results. A total of 9% of cases had iron deficiency (ID) and 6% had iron deficiency anemia (IDA), compared to 5% and 4% of controls respectively. The conditional logistic regression odds ratio for ID in patients with febrile seizures was 1.84 (95% CI, 1.02-3.31). Conclusion. Children with febrile seizures were almost twice as likely to be iron deficient as those with febrile illness alone. The results suggest that screening for ID should be considered in children presenting with febrile seizure.

Key Words: febrile seizure • iron deficiency • anemia

This version was published on May 1, 2009

Clinical Pediatrics, Vol. 48, No. 4, 420-426 (2009)
DOI: 10.1177/0009922809331800
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D. S. Hartfield
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Clinical Pediatrics, March 1, 2010; 49(2): 180 - 182.
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