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Acute Hemorrhagic Edema of Infancy: Report of 4 Cases and Review of the Current Literature

Department of Pediatrics, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany, michael.karremann{at}kikli.ma.uni-heidelberg.de

Alexander J. Jordan, MD

Department of Pediatrics, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

Nellie Bell, MD

Department of Pediatrics, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

Michael Witsch, MD

Department of Pediatrics, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

Matthias Dürken, MD

Department of Pediatrics, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

Acute hemorrhagic edema of infancy (AHEI) is a cutaneous leukocytoclastic vasculitis that usually occurs in children younger than 2 years of age. It is a rare disease characterized by mild fever, a violent onset of hemorrhagic skin lesions, and edema usually followed by a spontaneous and complete recovery. Although the etiology is unknown, AHEI often follows infections, drug treatment, or vaccination. In the present report, the authors describe 4 cases of AHEI and review the relevant literature.

Key Words: acute hemorrhagic edema • case report • cockade purpura • Finkelstein disease • infancy • Seidlmayer

This version was published on April 1, 2009

Clinical Pediatrics, Vol. 48, No. 3, 323-326 (2009)
DOI: 10.1177/0009922808323113


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