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Clinical Pediatrics
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Infantile-Onset Diabetes Mellitus: A 1-Year Follow-up Study

Ramaswamy Ganesh, MBBS, DNB, MNAMS

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India, ganeped79{at}rediffmail.com

Ravindrakumar Arvindkumar, MBBS

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India

Thiruvengadam Vasanthi, MBBS, DNB, MNAMS

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India

This study evaluates the clinical profiles and outcomes of children with infantile-onset diabetes mellitus (IODM) (onset at <1 year). Twelve infants with IODM presenting to our hospital from January 2003 to December 2007 are analyzed. All undergo thorough history, clinical examination, and investigations and are managed as per hospital-approved protocol and periodically followed up. Of 12 infants (3 boys and 9 girls), 9 have a family history of DM. The median age at onset is 2.5 months. Six infants have features suggestive of Wolcott-Rallison syndrome (WRS), 4 infants have type 1 DM, and 1 infant each has Fanconi-Bickel syndrome and maturity-onset diabetes of young. None have pancreatic agenesis or calculi. Human leukocyte antigen (HLA) typing shows DQ3 and DR15 alleles predominating. Two children with WRS died; the rest are being followed up. The incidence of IODM is increasing, with multiple syndromic associations rather than a single perspective.

Key Words: infant • diabetes mellitus • syndromes • insulin

This version was published on April 1, 2009

Clinical Pediatrics, Vol. 48, No. 3, 271-274 (2009)
DOI: 10.1177/0009922808324950
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