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Clinical Pediatrics
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Parental Satisfaction, Efficacy, and Adverse Events in 54 Patients Treated With Cantharidin for Molluscum Contagiosum Infection

Shelley Cathcart, MD

Department of Dermatology, UNC Hospital, University of North Carolina School of Medicine, Chapel Hill, North Carolina, shelley.cathcart{at}gmail.com

Jacqueline Coloe, BS

Department of Dermatology, UNC Hospital, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Dean S. Morrell, MD

Department of Dermatology, UNC Hospital, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Objective To study the efficacy, tolerability, and parental satisfaction of cantharidin in a patient population at a pediatric dermatology referral center.

Methods Chart review was completed for 110 patients who presented with molluscum infection and were treated with cantharidin. A total of 54 were available for follow-up by telephone interview regarding adverse effects, parental satisfaction, and overall clearance of the infection.

Results Of those who were reachable, 96% improved after treatment with cantharidin. Parental satisfaction was 78%. Patients received an average of 2.2 treatments irrespective of outcome. Overall, 46% of patients experienced adverse events, including pain, pruritus, secondary infection, brisk immune response, and temporary hypopigmentation and 9% experienced an adverse event that they classified as severe.

Conclusions The results contribute to the data supporting cantharidin as a safe and effective treatment of molluscum contagiosum. Compared with other treatments, it appears to be equally effective and well-tolerated and should be considered a potential front-line treatment.

Key Words: molluscum contagiosum • cantharidin

This version was published on March 1, 2009

Clinical Pediatrics, Vol. 48, No. 2, 161-165 (2009)
DOI: 10.1177/0009922808326085
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