Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Clinical Pediatrics
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0009922808319966v1
47/9/901    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Pichichero, M. E.
Right arrow Articles by Schwartz, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pichichero, M. E.
Right arrow Articles by Schwartz, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Pathogens Causing Recurrent and Difficult-to-Treat Acute Otitis Media, 2003-2006

Michael E. Pichichero, MD

University of Rochester Medical Center and Legacy Pediatrics, Rochester, New York, michael_pichichero{at}urmc.rochester.edu

Janet R. Casey, MD

University of Rochester Medical Center and Legacy Pediatrics, Rochester, New York

Alejandro Hoberman, MD

Children's Hospital of Pittsburgh, Pennsylvania

Richard Schwartz, MD

Inova Fairfax Hospital for Children, Falls Church, Virginia

This study sought to determine the microbiology of recurrent acute otitis media (AOM) and AOM treatment failure (AOMTF) in the context of widespread use of heptavalent pneumococcal conjugate vaccine (PCV7). In this retrospective cohort study, 244 AOM isolates obtained by tympanocentesis during 3 respiratory seasons—2003-2004 (n = 126), 2004-2005 (n = 52), 2005-2006 (n = 66)—from three geographically diverse pediatric populations were compared. Most isolates were from children less than 2 years old, who had received PCV7. For the 3 seasons the proportion of Streptococcus pneumoniae isolates was 35%, 35%, and 46% and for Haemophilus influenzae was 55%, 58%, and 39%, respectively (change in trend, P = .09). A total of 37%, 39%, and 50% of S. pneumoniae were penicillin nonsusceptible (PNSP) and 48%, 67%, and 50% of H. influenzae produced β-lactamase, respectively. Although H. influenzae remains the most frequently isolated pathogen in children with AOMTF or recurrent AOM, S. pneumoniae that are PNSP are reemerging as important organisms.

Key Words: acute otitis media • Streptococcus pneumoniae • Haemophilus influenzae • pneumococcal conjugate vaccine

This version was published on November 1, 2008

Clinical Pediatrics, Vol. 47, No. 9, 901-906 (2008)
DOI: 10.1177/0009922808319966
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
J. C. Harrington, S. M. S. Wong, C. V. Rosadini, O. Garifulin, V. Boyartchuk, and B. J. Akerley
Resistance of Haemophilus influenzae to Reactive Nitrogen Donors and Gamma Interferon-Stimulated Macrophages Requires the Formate-Dependent Nitrite Reductase Regulator-Activated ytfE Gene
Infect. Immun., May 1, 2009; 77(5): 1945 - 1958.
[Abstract] [Full Text] [PDF]