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Clinical Pediatrics
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Retrospective Analysis of Mycoplasma pneumoniae Infection in Pediatric Fatal Pneumonia in Guangzhou, South China

Zhi-Ying Ou, PhD

Guangzhou Children's Hospital

Rong Zhou, MS

Guangzhou Children's Hospital, South China Sea Institute of Oceanology, LED, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Beijing, (RZ, Z-HW), China

Feng-Hua Wang, MS

Guangzhou Children's Hospital

Jun-Peng Lu, MS

College of Veterinary Medicine, South China Agricultural University

Jian-Qing Xia, BC

Guangzhou Children's Hospital

Hui-Min Xia, MS

Guangzhou Children's Hospital

Jian-Tao Zhang, BC

Guangzhou Children's Hospital

Si-Tang Gong, PhD

Guangzhou Children's Hospital

Li Deng, BC

Guangzhou Children's Hospital

Zao-He Wu, PhD

South China Sea Institute of Oceanology, LED, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Beijing, (RZ, Z-HW), China

Qi-Yi Zeng, MS

Guangzhou Children's Hospital, gzcentralab{at}yahoo.com.cn

The objective of this study is to investigate the infection and distribution of Mycoplasma pneumoniae in autopsied pulmonary tissue of pediatric severe pneumonia. Mycoplasma pneumoniae nested polymerase chain reaction and immunohistochemistry were done on autopsy pulmonary tissue from 173 patients who died of severe pneumonia. Mycoplasma pneumoniae was identified in 135/173 (78.03%) and 114/173 (65.89%) samples of autopsied pulmonary tissue of lethal severe pneumonia via nested polymerase chain reaction and immunohistochemistry, respectively. The coincidence of both assays was 92.4%. Mycoplasma pneumoniae associated fatal pneumonia has showed an increasing trend from 1988 to 2005 in South China, and the fatality rate of Mycoplasma pneumoniae associated fatal pneumonia in infants, 1 to 12 months, has risen to 66.9% (97/145). Mycoplasma pneumoniae is a significant cause of severe pneumonia, it is a universal event in infants, and children have died of severe pneumonia in South China. Mycoplasma pneumoniae might be an important pathogen responsible for fatal pneumonia in Guangzhou area, South China.

Key Words: Mycoplasma pneumoniae • fatal pneumonia • pulmonary tissue • nested PCR • immunohistochemistry

This version was published on October 1, 2008

Clinical Pediatrics, Vol. 47, No. 8, 791-796 (2008)
DOI: 10.1177/0009922808318339
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