Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to register

Clinical Pediatrics
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0009922807311732v1
47/5/469    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Cohran, V. C.
Right arrow Articles by Heubi, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cohran, V. C.
Right arrow Articles by Heubi, J. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Bone Mineral Density in Children Exposed to Chronic Glucocorticoid Therapy

Valeria C. Cohran, MD

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Memorial Hospital, Chicago, Illinois, vcohran{at}childrensmemorial.org

Mark Griffiths, MD

University of Cincinnati College of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition and the General Clinical Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

James E. Heubi, MD

University of Cincinnati College of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition and the General Clinical Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

The objective of this study was to determine the impact of glucocorticoid exposure on lumbar spine bone mineral density (BMD) in children while concurrently measuring their calcium intake, serum 25-OH vitamin D levels, and physical activity. Forty-three patients (4-18 years) with renal glomerular diseases, dermatomyositis, inflammatory bowel disease, juvenile rheumatoid arthritis, post—solid organ transplant, and Duchenne muscular dystrophy were studied. All received at least 5 mg per day of prednisone for more than 6 months. The mean BMD z score was 0 ± 0.2 (range, –3.8 to +3.3) with 2 patients (5%) having z scores less than –2. The mean daily calcium intake was 1147 ± 145 g, with 1 patient having hypovitaminosis D (<15 ng/mL). The mean physical activity level was 7.8 ± 0.8 h/wk. The small reductions in BMD observed in our population suggest that screening is likely not warranted in all children with chronic glucocorticoid exposure.

Key Words: bone mineral density • children • glucocorticoids • osteoporosis

This version was published on June 1, 2008

Clinical Pediatrics, Vol. 47, No. 5, 469-475 (2008)
DOI: 10.1177/0009922807311732
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?