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Infants Born to Mothers With Anti-SSA/Ro Autoantibodies: Neonatal Outcome and Follow-up

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy, zuppaaa{at}rm.unicatt.it

Annalisa Fracchiolla, MD

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy

Francesco Cota, MD

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy

Francesca Gallini, MD

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy

Immacolata Savarese, MD

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy

Vito D'Andrea, MD

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy

Rita Luciano, MD

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy

Costantino Romagnoli, MD

Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy

Neonatal lupus syndrome is considered a model of passively acquired autoimmune disease. The first 10 newborns born to mothers with connective tissue disease and positive for anti-SSA/Ro antibodies enrolled in a follow-up program to evaluate the incidence of cardiac, hepatobiliary, hematologic, echoencephalographic, and cutaneous manifestations until 9 months of age are described in this study. No congenital heart block was observed, but only transient rhythm alterations were observed. In all, 1 infant showed typical neonatal lupus syndrome skin lesions at 3 months of age. During the neonatal period, echoencephalographic alterations were found more frequently, whereas at follow-up, hepatic and hematologic alterations were more often observed. In all, 1 baby showed persistent neutropenia. A standard program that enrolls all infants born to mothers with anti-SSA/Ro autoantibodies, who are at risk of developing neonatal lupus syndrome, should also include tests performed some time after birth, as a number of clinical manifestations might appear at a late stage.

Key Words: neonatal lupus • newborn • autoimmunity • anti-SSA/Ro

This version was published on April 1, 2008

Clinical Pediatrics, Vol. 47, No. 3, 231-236 (2008)
DOI: 10.1177/0009922807307264


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