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This version was published on December 1, 2007
Clinical Pediatrics, Vol. 46, No. 9, 806-811 (2007)
DOI: 10.1177/0009922807303929

Pharmacological Treatment of Anorexia Nervosa: A Retrospective Study in Preadolescents and Adolescents

G. Rossi

Department of Child Neurology and Psychiatry, IRCCS C. Mondino Foundation, University of Pavia, Pavia, Italy, giorossi{at}unipv.it

U. Balottin

Child Neuropsychiatry Unit, Department of Clinical and Biological Sciences, University of Insubria, Macchi Foundation Hospital, Varese, Italy

M. Rossi

Department of Child Neurology and Psychiatry, IRCCS C. Mondino Foundation, University of Pavia, Pavia, Italy

M. Chiappedi

Department of Child Neurology and Psychiatry, IRCCS C. Mondino Foundation, University of Pavia, Pavia, Italy, Child Neuropsychiatry and Rehabilitation Unit, Medical Center Santa Maria alle Fonti, Don Carlo Gnocchi Foundation, Salice Terme, Pavia, Italy

E. Fazzi

Department of Child Neurology and Psychiatry, IRCCS C. Mondino Foundation, University of Pavia, Pavia, Italy

G. Lanzi

Department of Child Neurology and Psychiatry, IRCCS C. Mondino Foundation, University of Pavia, Pavia, Italy

To date, studies addressing the role of pharmacotherapy in the treatment of anorexia nervosa are limited, especially in childhood and adolescence. The aim of this retrospective naturalistic study was to evaluate the efficacy and safety of pharmacotherapy in 19 anorexic preadolescents and adolescents referred, for the first time, to a specialist psychiatry unit. Almost all the patients showed an improvement both in their eating behaviors, and in their mood and obsessive symptoms. No evidence was found of dangerous adverse events. Combined with a multidisciplinary approach that includes nutritional rehabilitation and psychotherapy, adjunctive pharmacotherapy may be useful in addressing both eating disorder psychopathology and comorbid psychiatric disorders.

Key Words: anorexia nervosa • pharmacotherapy • adolescence


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