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Clinical Pediatrics
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Hypotonic Versus Isotonic Maintenance Intravenous Fluid Therapy in Hospitalized Children: A Systematic Review

Carolyn E. Beck, MD, MSc, FRCPC

Division of Paediatric Medicine and the Paediatric Outcomes Research Team, The Hospital for Sick Children, and the University of Toronto, Toronto, Ontario, Canada, carolyn.beck{at}sickkids.ca

A systematic review of studies comparing hypotonic versus isotonic intravenous maintenance fluids in hospitalized children was conducted to determine whether hypotonic solutions increase the risk of acute hyponatremia. Studies were identified from electronic databases and hand-searched reference lists. A total of 283 abstracts were reviewed, 55 full-text articles were retrieved, and 3 studies were included. All studies were observational and were overall inconclusive. All authors cautioned against the routine use of hypotonic maintenance fluids, but hypotonic fluid administration did not always explain the development of acute hyponatremia. Further evidence is required as to the appropriate maintenance solution for hospitalized children.

Key Words: intravenous infusions • hypotonic fluid • isotonic fluid • hyponatremia • pediatric

Clinical Pediatrics, Vol. 46, No. 9, 764-770 (2007)
DOI: 10.1177/0009922807303041
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M. L. Moritz and J. C. Ayus
Can the Routine Administration of Hypotonic Parenteral Fluids Be Justified?
Clinical Pediatrics, September 1, 2008; 47(7): 725 - 725.
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