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Neonatal Abstinence Syndrome and Cerebral Infarction Following Maternal Codeine Use During Pregnancy

Department of Pediatrics, Division of Neonatology, University of Kentucky College of Medicine, Lexington, ereyn2{at}uky.edu

Rosario Maria S. Riel-Romero, MD

Louisiana State University

Henrietta S. Bada, MD

Department of Pediatrics, Division of Neonatology, University of Kentucky College of Medicine, Lexington

Neonatal withdrawal from maternal drugs and medications is common in some NICUs. Codeine-containing cough preparations given to pregnant mothers have been identified as a cause of neonatal abstinence syndrome. However, many women do not consider prescription cough syrups when asked about drug use. Maternal medication or illicit drug use has been identified as a cause of perinatal arterial stroke. Since codeine is an opiate with similar pharmacodynamic effects to morphine, it is reasonable to investigate if maternal codeine use has effects on the fetus that are similar to other opiates. The authors present 2 cases of newborn infants with perinatal arterial stroke that may have been associated with in utero exposure to codeine. Physicians should ask about maternal medication use, including codeine-containing cough preparations, when evaluating newborn infants with evidence of cerebral infarction.

Key Words: perinatal stroke • neonatal abstinence • codeine

Clinical Pediatrics, Vol. 46, No. 7, 639-645 (2007)
DOI: 10.1177/0009922807300795


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