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Clinical Pediatrics
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Long-term Outcome in Children After Henoch-Schönlein Purpura Nephritis

Lavjay Butani, MD

Pediatric Nephrology, University of California, Davis Medical Center, Sacramento, California, lavjay.butani@ ucdmc.ucdavis.edu

Bruce Z. Morgenstern, MD

Pediatric Nephrology, Phoenix Children's Hospital, Phoenix, Arizona

This study investigated predictors of renal survival in children with Henoch-Schönlein purpura glomerulonephritis. Records of patients with Henoch-Schönlein purpura glomerulonephritis evaluated at our center, from 1953-1990, were reviewed. Data were abstracted from records of patients seen within 5 years. Others were mailed a questionnaire or contacted by telephone. Primary outcome measures were renal survival and presence of urinary abnormalities or hypertension. Of the 65 eligible patients with Henoch Schönlein purpura glomerulonephritis, follow-up data was obtainable for 81.5%. The median follow-up was 20 years. At last follow-up, 66% of patients had normal renal function and urinalyses, and 21% had progressed to end-stage renal disease. The only factor associated with the development of end-stage renal disease was the use of cytotoxic agents. There are no features at initial presentation that identify children at risk of disease progression. Close follow-up of all children with Henoch Schönlein purpura glomerulonephritis is warranted.

Key Words: Henoch-Schönlein purpura • glomerulonephritis • outcome • end-stage renal disease • hypertension.

Clinical Pediatrics, Vol. 46, No. 6, 505-511 (2007)
DOI: 10.1177/0009922806298896
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P. Weiss, J. Burnham, J. Feinstein, and C. Feudtner
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