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Clinical Pediatrics
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Nonfasting Low-Density Lipoprotein Testing: Utility for Cholesterol Screening in Pediatric Primary Care

Sarah de Ferranti, MD, MPH

Departments of Cardiology, Children's Hospital Boston, sarah.deferranti{at}cardio.chboston.org

David Shapiro, PhD

Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts

Robert Markowitz, MD

Department of Medicine, Children's Hospital Boston

Ellis Neufeld, MD, PhD

Division of Hematology, Children's Hospital Boston

Nader Rifai, PhD

Laboratory Medicine, Children's Hospital Boston

Henry Bernstein, DO

Division of General Pediatrics, Department of Pediatrics, Children's Hospital at Dartmouth, Dartmouth Medical School, Hanover, New Hampshire

This prospective study assessed the clinical application of a nonfasting low-density lipoprotein cholesterol measure in a pediatric primary care population. A homogenous direct low-density lipoprotein cholesterol assay was tested in healthy children, aged 4 to 12 years, at risk for hyperlipidemia, as defined by American Academy of Pediatrics, and including patients with incomplete family histories. This nonfasting homogeneous assay was comparable to modified ß quantification, the gold standard reference method of measuring low-density lipoprotein cholesterol, and the current recommended screening method, total cholesterol. Results from the study suggest that this nonfasting assay can provide more direct low-density lipoprotein cholesterol measurements for healthy children, with improved clinical utility and greater overall patient convenience in testing for important cholesterol abnormalities.

Key Words: hypercholesterolemia • low-density lipoprotein • homogenous direct assay • child • screening

Clinical Pediatrics, Vol. 46, No. 5, 441-445 (2007)
DOI: 10.1177/0009922806297752
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