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Clinical Pediatrics
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Reviews

Posttransplant Lymphoproliferative Disease: A Case Report and Review for the General Pediatrician

Christine R. Kincaid, MD

West Virginia University School of Medicine, Morgantown, West Virginia

Linda S. Nield, MD

West Virginia University School of Medicine, Morgantown, West Virginia, lnield@hsc .wvu.edu

Renee S. Moore, MD

West Virginia University School of Medicine, Morgantown, West Virginia

Frank G. Keller, MD

Division of Pediatric Hematology/Oncology/ BMT, Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Service, Atlanta, Georgia

This report describes a case of posttransplant lymphoproliferative disease in a 19-year-old male patient with an initial diagnosis of peritonsillar abscess. As the number of children receiving transplants continues to increase, the pediatrician must become familiar with the possible presentations of posttransplant lymphoproliferative disease and at least consider it as a diagnosis in any ill child under long-term treatment with immunosuppressive agents. The epidemiology, pathogenesis, clinical presentations, evaluation, prognosis, and treatment of posttransplant lymphoproliferative disease are reviewed for the primary care pediatrician.

Key Words: posttransplant lymphoproliferative disease • pediatric • Epstein-Barr virus

Clinical Pediatrics, Vol. 46, No. 4, 287-291 (2007)
DOI: 10.1177/0009922806294797
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