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Clinical Pediatrics
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Severe Human Metapneumovirus Infection in Hospitalized Children

Benjamin Estrada, MD

Divisions of Pediatric Infectious Diseases, University of South Alabama, Mobile, Alabama, bestrada@ usouthal.edu

Macharia Carter, MD

University of South Alabama, Mobile, Alabama; Division of Neonatology, Baylor College of Medicine, Houston, Texas

Sailen Barik, PhD

Departments of Biochemistry and Cell Biology, University of South Alabama, Mobile, Alabama

Rosa Vidal, MD

Pediatric Critical Care, University of South Alabama, Mobile, Alabama

Donald Herbert, PhD

Radiology, Biostatistics and Epidemiology, University of South Alabama, Mobile, Alabama

Keith M. Ramsey, MD

Brody School of Medicine at East Carolina University, Greenville, North Carolina

Human metapneumovirus is a recently discovered pathogen that causes upper and lower respiratory tract disease in children. This study describes the course of illness in hospitalized children with this infection. During a 6-month period, 11 children were diagnosed with human metapneumovirus infection by reverse transcription-polymerase chain reaction. Oxygen supplementation was required for 82% of patients. Severe disease developed in 45%, and mechanical ventilation was required. An apparent life-threatening event was the indication for hospitalization of 27% of patients infected with human metapneumovirus. Children with underlying asthma or neuromuscular disease had a prolonged hospitalization.

Key Words: metapneumovirus • life-threatening • wheezing

Clinical Pediatrics, Vol. 46, No. 3, 258-262 (2007)
DOI: 10.1177/0009922806293896
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