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Clinical Pediatrics
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Natural Course of Fever During Influenza Virus Infection in Children

Eitaro Suzuki, MD, PhD

Suzuki Pediatric Clinic, Ube, Japan, esuzuki{at}bronze.ocn.ne.jp

Kiyoshi Ichihara, MD, PhD

Department of Clinical Laboratory Sciences, Faculty of Health Sciences, Yamaguchi University School of Medicine, Ube, Japan

Andrew M. Johnson, MD, PhD

Department of Pediatrics (Emeritus), University of North Carolina School of Medicine, Chapel Hill, North Carolina

During the 2001-2002 epidemic of influenza virus A/H1N1, A/H3N2, and B, the authors obtained detailed profiles of fever from 118 infected children. The only treatment given was acetaminophen for temperatures greater than 39.0°C. Fever was most prominent in A/H3N2 and young children. Secondary fever was observed frequently at 72 to 132 hours in all types. The duration of fever was associated negatively with the age of the child and positively with the maximal temperature. The information will be no longer available in current era of oseltamivir therapy.

Key Words: influenza virus • virus isolation • fever pattern • multiple regression analysis

Clinical Pediatrics, Vol. 46, No. 1, 76-79 (2007)
DOI: 10.1177/0009922806289588
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