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Clinical Pediatrics
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Infants Fed Docosahexaenoic Acid- and Arachidonic Acid-Supplemented Formula Have Decreased Incidence of Bronchiolitis/Bronchitis the First Year of Life

Nitida Pastor, PhD

Mead Johnson Nutritionals, Madrid, Spain

Begoña Soler, MD

E-C-BIO S.L. Estudios Científicos, Madrid, Spain

Susan Hazels Mitmesser, PhD

Mead Johnson Nutritionals, Madrid, Spain

Paul Ferguson, PhD

Mead Johnson Nutritionals, Madrid, Spain

Carlos Lifschitz, MD

Mead Johnson Nutritionals, Madrid, Spain, Division of Gastroenterology and Nutrition, Texas Children’s Hospital and Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX

To assess the effect of docosahexaenoic acid and arachidonic acid supplementation in infant formula on the incidence of respiratory illnesses, pediatricians assigned infants to receive docosahexaenoic acid/arachinonic acid-supplemented formula or control formula. Anthropometrics, medical history, and illnesses were reported. Among 1342 infants, there was a higher incidence of bronchiolitis in control versus docosahexaenoic acid/arachinonic acid-supplemented groups at 5, 7, and 9 months (P < .01). Weight, length, and head circumference were similar for both groups. Infants fed formula supplemented with 0.32% docosahexaenoic acid and 0.64% arachidonic acid experienced a lower incidence of bronchiolitis compared with infants fed formula supplemented with no docosahexaenoic acid/arachidonic acid or lower levels of docosahexaenoic acid/arachidonic acid in the first year of life.

Key Words: docosahexaenoic acid • arachidonic acid • infant formula • bronchiolitis • respiratory illness

Clinical Pediatrics, Vol. 45, No. 9, 850-855 (2006)
DOI: 10.1177/1073858406289801
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