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Acellular Pertussis Vaccine Boosters Combined With Diphtheria and Tetanus Toxoid Boosters for Adolescents: Safety and Immunogenicity Assessment When Preceded by Different 5-Dose DTaP/DTwP Schedules

Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642 michael_pichichero{at}urmc.rochester.edu

Janet R. Casey, MD

Anne B. Francis, MD

Steven M. Marsocci, MD

Marie Murphy, MD

William Hoeger, MD

Carolyn Cleary, MD

University of Rochester Medical Center, Elmwood Pediatric Group, Rochester, New York

A sixth dose of tetanus, diphtheria, acellular pertussis (Tdap) vaccine in adolescents might produce a differing reactogenicity and/or immunogenicity response depending on the composition of the 5 prior doses of DTaP or DT-whole cell pertussis (DTwP) vaccine. Reactions and immune responses following receipt of the Sanofi Pasteur (Adacel) and GlaxoSmithKline (Boostrix) Tdap vaccines were assessed in 229 adolescents. No differences were observed for reactions to either Tdap vaccine regardless of the prior DTaP/DTwP vaccination history. Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic.

Key Words: pertussis • vaccines • acellular pertussis • diphtheria • tetanus • clinical trials

Clinical Pediatrics, Vol. 45, No. 7, 613-620 (2006)
DOI: 10.1177/0009922806289593


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