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Plasma Glucose Concentrations in Profound Neonatal Hypoglycemia

Division of Neonatology, Department of Pediatrics, Ahmanson Pediatric Center, Los Angeles, CA

Laura Flores-Sarnat, MD

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA

Harvey B. Sarnat, MD

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA

Sergio J. Farber, PhD

Division of Neurology, Department of Pediatrics, Alberta Children’s Hospital, Calgary, Canada

Charles F. Simmons, MD

Division of Neonatology, Department of Pediatrics, Ahmanson Pediatric Center, Los Angeles, CA

The study goal was to define low thresholds of plasma glucose concentrations that constitute profound hypoglycemia. Population analysis was performed on research publications on neonatal hypoglycemia ascertained by a Medline search. Eligible patients had neurological sequelae associated directly and primarily with hypoglycemia (profound hypoglycemia). Of 89 infants, more than 95% had plasma glucose levels of less than 25 mg/dL that were first detected at more than 10 hours of age. A breakdown of study patients according to those with or without neurological sequelae, who were exposed to a similar degree of hypoglycemia, showed a combined incidence of neurological injury of 21%, with 95% confidence interval from 14% to 27%.

Clinical Pediatrics, Vol. 45, No. 6, 550-558 (2006)
DOI: 10.1177/0009922806290610


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