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Analysis of Children with Peripheral Lymphadenopathy

Department of Pediatric Oncology and Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey

Murat Cakir, MD

Department of Pediatric Oncology and Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey

Emin Sözen, MD

Department of Pediatric Oncology and Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey

Umit Cobanoglu, MD

Department of Pediatric Oncology and Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey

In this study, the clinical and laboratory features of children with lymphadenopathy were evaluated. Over a 3-year period, 126 patients were referred to the clinic for lymphadenopathy. Twenty-eight of cases have diseases mimicking lymphadenopathy; 98 (mean age: 86 ± 55 months) have lymphadenopathy. Localized, limited, and generalized involvement was found in 52%, 30%, and 18% of patients. The most common localization was the head and neck region. The causes of lymphadenopathy were benign diseases in 75 patients. Sixty percent were reactive lymphadenopathy, 39% were lymphadenitis. Lymphadenitis was more frequently localized and bigger than 3 cm compared with reactive adenopathy (p = .02, p = .004). Twenty-three patients have malignant diseases whose mean age was higher than others (p = .002). The enlargement of supraclavicular nodes was more likely due to malignant disease (p = .001). The risk of malignant disease was higher in patients who had generalized lymphadenopathy, lymph nodes bigger than 3 cm, hepatosplenomegaly, and high lactate dehydrogenase levels. In conclusion, this study pointed out the important clues for the differential diagnosis, which were present in the history, physical, and laboratory findings.

Clinical Pediatrics, Vol. 45, No. 6, 544-549 (2006)
DOI: 10.1177/0009922806290609


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