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Clinical Pediatrics
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Evaluation of Prolonged aPTT Values in the Pediatric Population

Mona D. Shah, MD

Department of Pediatrics, Rainbow Babies and Children’s Hospital, University Hospitals of Cleveland, Cleveland, OH

Mary Ann O’Riordan, MS

Divisions of Pediatric Pharmacology and Critical Care, Rainbow Babies and Children’s Hospital, University Hospitals of Cleveland, Cleveland, OH

Sarah W. Alexander, MD

Divisions of Pediatric Hematology and Oncology, Rainbow Babies and Children’s Hospital, University Hospitals of Cleveland, Cleveland, OH

To assess the likelihood of significant bleeding disorders in children with prolonged activated partial thromboplastin times (aPTTs), a retrospective chart review was performed. Data analyses determined that in the absence of symptoms and a negative family history, the diagnosis of a bleeding disorder was unlikely in an individual with a prolonged aPTT (negative predictive value = 80%). Conversely, a prolonged aPTT was predictive (positive predictive value = 62%) in the presence of both clinical symptoms and a documented family history. The scope of laboratory investigation in any child with a prolonged aPTT should be tempered by the clinical presentation and the associated personal and family histories.

Clinical Pediatrics, Vol. 45, No. 4, 347-353 (2006)
DOI: 10.1177/000992280604500407
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