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Brain Imaging Findings in Neonatal Hypoglycemia: Case Report and Review of 23 Cases

Division of Neonatology, Department of Pediatrics, Ahmanson Pediatric Center, and Department of Imaging, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California

Laura Flores-Sarnat, MD

Division of Neurology, Department of Pediatrics, Alberta Children’s Hospital, Calgary, Canada

Harvey B. Sarnat, MD

Division of Neurology, Department of Pediatrics, Alberta Children’s Hospital, Calgary, Canada

Franklin G. Moser, MD

Mark Taper Foundation Imaging Center, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California

Charles F. Simmons, MD

Division of Neonatology, Department of Pediatrics, Ahmanson Pediatric Center, and Department of Imaging, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California

A hypoglycemic infant with secondary occipital brain injury defined by serial computed tomography and magnetic resonance imaging is described. An additional 22 similar cases were previously published in the English language literature. A total of 23 cases (including the present case) were reviewed. Abnormal brain imaging findings are associated with profound hypoglycemia and show involvement of the occipital lobes in 82% of affected newborns. Half of these infants had visual impairment, and their median and range of plasma glucose values, and postnatal age when hypoglycemia was first detected, were 7 mg/dL (range, 2-26 mg/dL) and 48 hours (range, 1-72 hours), respectively.

Clinical Pediatrics, Vol. 44, No. 9, 783-790 (2005)
DOI: 10.1177/000992280504400906


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