Clinical Pediatrics

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baysun, S.
Right arrow Articles by Gürer, Y. K. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baysun, S.
Right arrow Articles by Gürer, Y. K. Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Clinical Pediatrics, Vol. 44, No. 9, 771-776 (2005)
DOI: 10.1177/000992280504400904

A Comparison of Buccal Midazolam and Rectal Diazepam for the Acute Treatment of Seizures

Sahika Baysun, MD

Department of Pediatrics, Dr. Sami Ulus Children’s Hospital, Ankara, Turkey

Ömer Faruk Aydin, MD

Department of Pediatric Neurology, Dr. Sami Ulus Children’s Hospital, Ankara, Turkey

Emel Atmaca, MD

Department of Pediatrics, Dr. Sami Ulus Children’s Hospital, Ankara, Turkey

Y. K. Yavuz Gürer, MD

Department of Pediatric Neurology, Dr. Sami Ulus Children’s Hospital, Ankara, Turkey

In this study, the authors aimed to evaluate buccal midazolam as a practical and safe alternative medication for children who suffer from seizures in the emergency setting and in home practice or anywhere. The effects and side effects of buccal midazolam and rectal diazepam were compared in the treatment of acute convulsions in 43 children, ranging in age from 2 months to 12 years who were seen at the emergency service of the children hospital. Midazolam was given on the even days of the month and diazepam was given on the odd days. In the midazolam group, the seizures of 18/23 (78%) patients terminated in 10 minutes; however 5/23 (22%) patients did not respond. In the diazepam group 17/20 (85%) patients responded in 10 minutes, but 3/20 (15%) did not respond. Midazolam was found to be as effective as diazepam and the difference was not statistically significant (p<0.05). Response periods of the 2 drugs showed no significant difference (p>0.05). The need for a second drug for seizures that did not stop with the first drug was equal, and the difference was not statistically significant (p>0.05). They did not observe any serious complications. In conclusion, buccal midazolam is safe and as effective as rectal diazepam for the treatment of seizures.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
A. Mpimbaza, G. Ndeezi, S. Staedke, P. J. Rosenthal, and J. Byarugaba
Comparison of Buccal Midazolam With Rectal Diazepam in the Treatment of Prolonged Seizures in Ugandan Children: A Randomized Clinical Trial
Pediatrics, January 1, 2008; 121(1): e58 - e64.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
T. A. Glauser
Designing Practical Evidence-Based Treatment Plans for Children With Prolonged Seizures and Status Epilepticus
J Child Neurol, May 1, 2007; 22(5_suppl): 38S - 46S.
[Abstract] [PDF]