This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Vachvanichsanong, P. Articles by Dissaneewate, P. Search for Related Content PubMed PubMed Citation Articles by Vachvanichsanong, P. Articles by Dissaneewate, P. Social Bookmarking                   What's this?

Congenital and Infantile Nephrotic Syndrome in Thai Infants

Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand

Winyou Mitarnun, MD

Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand

Kobkul Tungsinmunkong, MD

Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand

Pornsak Dissaneewate, MD

Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand

Congenital and infantile nephrotic syndrome reported from the Eastern world is rare and might be a different entity from that in the West. In a retrospective review of 10 nephrotic syndrome in Thai infants (5 girls and 5 boys), 7 were diagnosed with congenital nephrotic syndrome and 3 with infantile nephrotic syndrome. Two had congenital nephrotic syndrome secondary to congenital syphilis. All had edema, ascites, and failure to thrive. Of the 3 patients tested for thyroid function, all showed hypothyroidism. Two patients developed renal failure. Renal tissue was examined from 4 patients from 3 biopsies and 2 autopsies; only 1 patient showed tubular microcysts. Symptomatic therapy was performed concurrently with penicillin therapy in 2 patients having congenital syphilis. Prednisolone, cyclophosphamide, captopril, and enalapril were tried in some patients, with little effect. Five patients died from respiratory failure complicated by later infection, 1 patient died from renal failure, and 4 patients were lost to follow-up. Nephrotic syndrome in the first year of life in the Eastern world is rare. Prognosis of nephrotic syndrome in Thai infants at this time is still poor.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. F. Adekanmbi, O. B. Ogunfowora, T. A. Ogunlesi, M. M. Ogundeyi, A. O. Olowu, and S. Adetoun Sotimehin Congenital Nephrotic Syndrome in a Nigerian Infant J Trop Pediatr, August 1, 2007; 53(4): 287 - 291. [Abstract] [Full Text] [PDF]