This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Cleper, R. Articles by Davidovits, M. Search for Related Content PubMed PubMed Citation Articles by Cleper, R. Articles by Davidovits, M. Social Bookmarking                         What's this?

Prevalence of Vesicoureteral Reflux in Neonatal Urinary Tract Infection

Pediatric Nephrology and Dialysis Unit, Schneider Children’s Medical Center of Israel, Petah Tikva, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Irit Krause, MD

Pediatric Nephrology and Dialysis Unit, Schneider Children’s Medical Center of Israel, Petah Tikva, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Bella Eisenstein, MD

Pediatric Nephrology and Dialysis Unit, Schneider Children’s Medical Center of Israel, Petah Tikva, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Miriam Davidovits, MD

Pediatric Nephrology and Dialysis Unit, Schneider Children’s Medical Center of Israel, Petah Tikva, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Vesicoureteral reflux (VUR) after a first episode of urinary tract infection (UTI) is apparently diagnosed much more frequently (25%-40%) in children than in neonates. The aims of the study were to determine the actual rate of VUR in neonates with UTI and to define the clinical clues to its diagnosis. The study sample included term infants with a diagnosis of UTI during their first month of life who were seen in this hospital between January 1997 and May 1999. All infants underwent complete diagnostic work-up (renal ultrasound and voiding cystourethrography [VCUG]). The medical files were reviewed for patient sex, age at UTI diagnosis, laboratory findings (including causative pathogen), and ultrasonographic findings. These parameters were correlated with the finding of VUR on VCUG. Sixty-four neonates (55 males, 9 females) with UTI were included in this study. UTI was 6 times more common in males than females, although the incidence of VUR was equal between the sexes (about 20%). The presence of VUR was associated with a significantly younger age at presentation of UTI (11.4±4 vs 16.9±6.6 days, p<0.01). VUR was diagnosed at a fourfold higher rate in neonates with Klebsiella-induced UTI compared to those with E. Coli-UTI. In 80% of those with significantly abnormal ultrasonographic findings VUR was found on VCUG. Jaundice was noted at UTI diagnosis 3 times more often in infants with VUR, and elevated creatinine level, 2.5 times more often.

Clinical Pediatrics, Vol. 43, No. 7, 619-625 (2004)
DOI: 10.1177/000992280404300706


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				E. Siomou, V. Giapros, A. Fotopoulos, M. Aasioti, F. Papadopoulou, A. Serbis, A. Siamopoulou, and S. Andronikou Implications of 99mTc-DMSA Scintigraphy Performed During Urinary Tract Infection in Neonates Pediatrics, September 1, 2009; 124(3): 881 - 887. [Abstract] [Full Text] [PDF]

				R. Lim Vesicoureteral Reflux and Urinary Tract Infection: Evolving Practices and Current Controversies in Pediatric Imaging Am. J. Roentgenol., May 1, 2009; 192(5): 1197 - 1208. [Abstract] [Full Text] [PDF]

				G. Williams, J. T. Fletcher, S. I. Alexander, and J. C. Craig Vesicoureteral Reflux J. Am. Soc. Nephrol., May 1, 2008; 19(5): 847 - 862. [Abstract] [Full Text] [PDF]