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Benefits of Oral Supplementation With and Without Synbiotics in Young Children With Acute Bacterial Infections

Federal Dairy Research Center, Kiel, Germany

K. Heller, PhD

Federal Dairy Research Center, Kiel, Germany

M. McCue, RD

Abbott Laboratories, Abbott Park, IL, USA

C. Llamas, MS

Abbott Laboratories, Abbott Park, IL, USA

W. Lam, PhD

Abbott Laboratories, Abbott Park, IL, USA

H. Burow, MD

Private Pediatric Clinic, Oberkirch, Germany

M. Kindling-Rohracker, MD

Private Pediatric Clinic, Rodgau, Germany

W. Fischer, MD

Universitat Kinderheilkunde Heidelberg, Heidelberg, Germany

H. C. Sengespeik, MD

Universitat Kinderheilkunde Munich, Munich, Germany

G. M. Comer, MD

Abbott Laboratories, Abbott Park, IL, USA

P. Alarcon, MD

Acutely ill children (n = 129) aged 1-6 years receiving antibiotic therapy were randomized to receive a nutritional supplement with (PS) or without (P) synbiotics or a fruit-flavored drink (D) with their medications. Group PS had significantly greater weight gains (versus D) following antibiotic therapy. The percentages of subjects without bacterial illnesses 14 days following antibiotic therapy were as follows: 94.3% (PS), 87.8% (D), and 80.6% (P). PS (vs D) significantly increased fecal Lactobacillus in a subset of subjects. Oral supplements increase energy intake and promote weight gain in acutely ill children receiving antibiotics; synbiotics may confer additional benefits by increasing bifidobacteria levels.

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