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Clinical Pediatrics
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Long-term Efficacy of Polyethylene Glycol 3350 for the Treatment of Chroni Constipation in Children with and without Encopresis

Dinesh S. Pashankar, MD, MRCP

Division of Gastroenterology, 2864 JPP, Children's Hospital of Iowa, 200 Hawkins Drive, Iowa City, IA 52242-1083

Warren P. Bishop, MD

Division of Gastroenterology, Children's Hospital of Iowa, University of Iowa, Iowa City, Iowa

Vera Loening-Baucke, MD

Division of General Pediatrics, Children's Hospital of Iowa, University of Iowa, Iowa City, Iowa

Seventy-four children (43 with chronic constipation, 31 with constipation and encopresis) treated with polyethylene glycol 3350 (PEG) for longer than 3 months were studied to assess long-term efficacy. The mean duration of PEG therapy was 8.4 months (range, 3-30). Weekly stool frequency, stool consistency, and symptoms associated with constipation improved significantly with PEG therapy in all 74 patients. In 31 children with encopresis, soiling ceased completely in 16 patients and frequency of soiling decreased significantly in all others. The average effective long-term dose of PEG was 0.7 g/kg/day. Long-term PEG therapy is effective for the treatment of chronic constipation with and without encopresis in children.

Clinical Pediatrics, Vol. 42, No. 9, 815-819 (2003)
DOI: 10.1177/000992280304200907
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