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Comparison of Intelligence, School Readiness Skills, and Attention in In-Utero Drug-Exposed and Nonexposed Preschool Children

The Johns Hopkins University School of Medicine, Department of Pediatrics, 600 N. Wolfe St. Room CMSC-144, Baltimore, MD 21287-3144

Margaret B. Pulsifer, PhD

The Johns Hopkins University School of Medicine, Departments of Psychiatry and Behavioral Sciences, Baltimore, Maryland

Mary Leppert, MD

The Johns Hopkins University School of Medicine, Departments of Pediatrics, Baltimore, Maryland; The Johns Hopkins University School of Medicine, Departments of The Kennedy Krieger Institute, Baltimore, Maryland

Sheryl Rimrodt, MD

The Johns Hopkins University School of Medicine, Departments of The Kennedy Krieger Institute, Baltimore, Maryland

Harolyn Belcher, MD

The Johns Hopkins University School of Medicine, Departments of Pediatrics, Baltimore, Maryland; The Johns Hopkins University School of Medicine, Departments of The Kennedy Krieger Institute, Baltimore, Maryland

Children with in-utero drug exposure (IUDE) may be at risk for poor neurodevelopmental outcomes. The objective of this study was to determine the association between IQ school readiness skills, and self-regulation behavior in IUDE children (n=103) and non IUDE-exposed children (n=33) at age 4 years. Mean IQ or school readiness scores did not significantly differ by IUDE exposure; however, both groups scored approximately 1 standard deviation below the mean for both IQ and school readiness skills. The IUDE group earned a significantly higher mean score (thereby performing poorer) than the nonexposed group on focusing and inattentive behavior. Factors associated with poor school readiness skills for all children (IUDE exposed and nonexposed) were not attending a preschool program and lower caregiver education level. Assuring high-risk children are identified and referred for early intervention services as well as treated for inattention behavior is crucial for their academic success.

Clinical Pediatrics, Vol. 42, No. 8, 727-739 (2003)
DOI: 10.1177/000992280304200809


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				M. B. Pulsifer, A. M. Butz, M. O'Reilly Foran, and H. M. E. Belcher Prenatal Drug Exposure: Effects on Cognitive Functioning at 5 Years of Age Clinical Pediatrics, February 1, 2008; 47(1): 58 - 65. [Abstract] [PDF]