This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Vanderhoof, J. A. Articles by Orenstein, S. R. Search for Related Content PubMed PubMed Citation Articles by Vanderhoof, J. A. Articles by Orenstein, S. R. Social Bookmarking                         What's this?

Efficacy of a Pre-thickened Infant Formula: A Multicenter, Double-Blid, Randomized, Placebo-Controlled Parallel Group Trial in 104 Infants with Symptomatic Gastroesophageal Reflux

Joint Section of Pediatric Gastroenterology and Nutrition, University of Nebraska Medical Center and Creighton University, Omaha, Nebraska

J. Roberto Moran, MD

Cheryl L. Harris, MS

Kimberly L. Merkel, RPh

Mead Johnson Nutritionals, Evansville,Indiana

Susan R. Orenstein, MD

Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

To evaluate a pre-thickened formula (Enfamil AR1/2) for regurgitant gastroesophageal reflux, 104 infants were enrolled in a 5-week, multi center, double-blind, randomized, place bo controlled parallel group trial. The Enfamil AR group showed greater symptom reduction by the end of the first week: percent feedings with any regurgitation (p=0.045), total regurgitation volume score (p=0.035), and percent feedings with choke-gag-cough (p=0.00⁴). The most symptomatic infants at baseline had a reduction in trouble sleeping significantly with Enfamil AR by the end of the study (p=0.030). This formula flows through a standard nipple, reduces regurgitation and choking-gagging-coughing within a week, and improves sleep in the most symptomatic babies by 5 weeks, without causing constipation.

Clinical Pediatrics, Vol. 42, No. 6, 483-495 (2003)
DOI: 10.1177/000992280304200602


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. J. Joeckel and S. K. Phillips Overview of Infant and Pediatric Formulas Nutr Clin Pract, June 1, 2009; 24(3): 356 - 362. [Abstract] [Full Text] [PDF]

				A. Horvath, P. Dziechciarz, and H. Szajewska The Effect of Thickened-Feed Interventions on Gastroesophageal Reflux in Infants: Systematic Review and Meta-analysis of Randomized, Controlled Trials Pediatrics, December 1, 2008; 122(6): e1268 - e1277. [Abstract] [Full Text] [PDF]

				A B Chang, T J Lasserson, T O Kiljander, F L Connor, J T Gaffney, and L A Garske Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux BMJ, January 7, 2006; 332(7532): 11 - 17. [Abstract] [Full Text] [PDF]

				A. B. Chang and W. B. Glomb Guidelines for Evaluating Chronic Cough in Pediatrics: ACCP Evidence-Based Clinical Practice Guidelines Chest, January 1, 2006; 129(1_suppl): 260S - 283S. [Abstract] [Full Text] [PDF]

				D Sifrim Relevance of volume and proximal extent of reflux in gastro-oesophageal reflux disease Gut, February 1, 2005; 54(2): 175 - 178. [Abstract] [Full Text] [PDF]