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Clinical Pediatrics
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*Diarrhea
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Clostridium Diffi cile-Associated Diarrhea in a Pediatric Hospital

Jordan G. Spivack, MD, PhD

Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania

Stephen C. Eppes, MD

Joel D. Klein, MD

Division of Infectious Disease, Nemours Children's Clinic-Wilmington, Alfred I. du Pont Hospital for Children, Wilmington, Delaware

This retrospective cohort analysis examined the risk factors, symptoms, and severity of disease associated with C. difficile in pediatric inpatients. Risk factors for a C. difficile-positive test were an oncologic diagnosis, diarrhea of more than 2 days' duration, and gastrointestinal symptoms, especially abdominal pain. Over a 3.5-year period, there was a total of 22 C. difficile-positive patients, and most had mild, self-limiting diarrheal illness. No cases of C. difficile diarrhea were identified. Seventy-eight percent of the C. difficile-positive patients were found to have alternate risk factors for diarrhea. Our data indicate that C. difficile rarely causes severe diarrhea in pediatric inpatients and that C. difficile testing should be limited to patients with severe prolonged diarrhea and abdominal pain.

Clinical Pediatrics, Vol. 42, No. 4, 347-352 (2003)
DOI: 10.1177/000992280304200407
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?