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Clinical Pediatrics
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Abdominal Pain Associated with Lactose Ingestion in Children with Lactose Intolerance

David A. Gremse, MD

A. Scott Greer, MD

Jonathan Vacik, MD

Jack A. Dipalma, MD

The Division of Pediatric Gastroenterology and Nutrition, and the Division of Gastroenterology, Department of Internal Medicine, University of South Alabama College of Medicine, Mobile, Alabama

The causal relationship between lactose ingestion and gastrointestinal symptoms is questionable. The aim of this study was to assess symptoms associated with milk ingestion in children with lactose maldigestion. Thirty children (11 males) age 3 to 17 years with lactose maldigestion were studied. In a double-blind, crossover design, subjects ingested 240 m L daily of either lactose-hydrolyzed or lactose-containing milk for 14 days. Diaries were kept daily that recorded diet, medication use, and symptoms. There was a significant increase in abdominal pain experienced by study participants during the lactose ingestion period when compared to the lactose-free period. We conclude that ingestion of 12 g of lactose daily is associated with increased abdominal pain in susceptible children with lactose maldigestion. A trial of dietary lactose restriction may be beneficial in reducing abdominal pain in children with lactose maldigestion.

Clinical Pediatrics, Vol. 42, No. 4, 341-345 (2003)
DOI: 10.1177/000992280304200406
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M. B. Heyman and for the Committee on Nutrition
Lactose Intolerance in Infants, Children, and Adolescents
Pediatrics, September 1, 2006; 118(3): 1279 - 1286.
[Abstract] [Full Text] [PDF]