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Clinical Pediatrics
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Obstructive Uropathy: An Important Cause of Chronic Renal Failure in Children

Karl S. Roth, MD

Department of Pediatrics, Biochemistry and Molecular Biophysics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23229

Harry P. Koo, MD

Pediatric Urology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23229

Stephanie E. Spottswood, MD

Radiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23229

James Cm Chan, MD

Department of Pediatrics, Biochemistry and Molecular Biophysics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23229

Care of individuals with renal failure continues to impose a tremendous burden on our national health care budget. Chronic renal failure is the final common denominator of a multiplicity of pathologic processes, some of which progress silently over years. Of these, obstructive uropathy is a prominent cause of kidney failure, accounting for 16.5% of all pediatric renal transplants in 1997. The pathophysiology of obstructive uropathy is reviewed as the basis for a differential diagnosis. In view of the significant role played by obstructive uropathy in the development of renal failure, early and definitive treatment of this clinical entity is imperative.

Clinical Pediatrics, Vol. 41, No. 5, 309-314 (2002)
DOI: 10.1177/000992280204100503
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