This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (20) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gremse, D. A. Articles by Crutchfield, A. Search for Related Content PubMed PubMed Citation Articles by Gremse, D. A. Articles by Crutchfield, A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Constipation Social Bookmarking                   What's this?

Comparison of Polyethylene Glycol 3350 and Lactulose for Treatment of Chronic Constipation in Children

The Division of Pediatric Gastroenterology and Nutrition, University of South Alabama College of Medicine, Mobile, Alabama

Jamie Hixon

Alysia Crutchfield

The Division of Pediatric Gastroenterology and Nutrition, University of South Alabama College of Medicine, Mobile, Alabama

Polyethylene glycol (PEG) 3350 and lactulose were compared in an unblinded, randomized, crossover design for treatment of constipation in 37 children aged 2 to 16 years. Subjects received lactulose (1.3 g/kg/d divided twice daily up to 20 g) or PEG 3350 (10 g/m²/day) for 2 weeks. PEG 3350 significantly decreased the total colonic transit time compared to lactulose (47.6 +2.7 vs 55.3 ±2.4 hours, mean ±SE, PEG 3350 vs lactulose, respectively, p = 0.038). The stool frequency, form, and the ease of passage were similar for each laxative. Polyethylene glycol 3350 is an effective laxative for the treatment of chronic constipation in children.

Clinical Pediatrics, Vol. 41, No. 4, 225-229 (2002)
DOI: 10.1177/000992280204100405


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. Chung, A. Cheng, and R. D. Goldman Polyethylene glycol 3350 without electrolytes for treatment of childhood constipation Can Fam Physician, May 1, 2009; 55(5): 481 - 482. [Abstract] [Full Text] [PDF]

				M A M Pijpers, M M Tabbers, M A Benninga, and M Y Berger Currently recommended treatments of childhood constipation are not evidence based: a systematic literature review on the effect of laxative treatment and dietary measures Arch. Dis. Child., February 1, 2009; 94(2): 117 - 131. [Abstract] [Full Text] [PDF]

				D Candy and J Belsey Macrogol (polyethylene glycol) laxatives in children with functional constipation and faecal impaction: a systematic review Arch. Dis. Child., February 1, 2009; 94(2): 156 - 160. [Abstract] [Full Text] [PDF]

				V. Loening-Baucke and D. S. Pashankar A Randomized, Prospective, Comparison Study of Polyethylene Glycol 3350 Without Electrolytes and Milk of Magnesia for Children With Constipation and Fecal Incontinence Pediatrics, August 1, 2006; 118(2): 528 - 535. [Abstract] [Full Text] [PDF]

				R Arora and R Srinivasan Is polyethylene glycol safe and effective for chronic constipation in children? Arch. Dis. Child., June 1, 2005; 90(6): 643 - 646. [Full Text] [PDF]

				W Voskuijl, F de Lorijn, W Verwijs, P Hogeman, J Heijmans, W Makel, J Taminiau, and M Benninga PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial Gut, November 1, 2004; 53(11): 1590 - 1594. [Abstract] [Full Text] [PDF]

				E. A Bell and G. C Wall Pediatric Constipation Therapy Using Guidelines and Polyethylene Glycol 3350 Ann. Pharmacother., April 1, 2004; 38(4): 686 - 693. [Abstract] [Full Text] [PDF]

				D. S. Pashankar, W. P. Bishop, and V. Loening-Baucke Long-term Efficacy of Polyethylene Glycol 3350 for the Treatment of Chroni Constipation in Children with and without Encopresis Clinical Pediatrics, November 1, 2003; 42(9): 815 - 819. [Abstract] [PDF]

				D. S. Pashankar, V. Loening-Baucke, and W. P. Bishop Safety of Polyethylene Glycol 3350 for the Treatment of Chronic Constipation in Children Arch Pediatr Adolesc Med, July 1, 2003; 157(7): 661 - 664. [Abstract] [Full Text] [PDF]