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Clinical Pediatrics, Vol. 40, No. 7, 381-387 (2001)
DOI: 10.1177/000992280104000704

A Randomized, Blinded Comparison of Chioral Hydrate and Midazolam Sedation in Children Undergoing Echocardiography

Derek S. Wheeler, MD

Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, Naval Medical Center, San Diego, CA

Richard A. Jensen, CDR, MC, USNR

Department of Pediatrics, Naval Medical Center, San Diego, CA

W. Bradley Poss, CDR, MC, USN

Department of Pediatrics, Naval Medical Center, San Diego, CA; c/o Clinical Investigation Department (KCA), Naval Medical Center San Diego, 34800 Bob Wilson Drive, Ste. 5, San Diego, CA 921 34-1005

The objective of this prospective, randomized, and blinded study was to compare the use of chloral hydrate versus oral midazolam sedation in children undergoing echocardiography. No adverse effects (nausea, vomiting, paradoxical agitation, or significant deviations from baseline vital signs) were noted with either medication. No differences were noted in onset of sedation between the 2 groups, however, the time to complete recovery was significantly shorter with midazolam than with chloral hydrate. The children in the chloral hydrate group had a significantly deeper level of sedation and were more likely to receive a more nearly comprehensive echocardiographic evaluation.


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This article has been cited by other articles:


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American Academy of Pediatrics, American Academy of Pediatric Dentistry, C. J. Cote, S. Wilson, and the Work Group on Sedation
Guidelines for Monitoring and Management of Pediatric Patients During and After Sedation for Diagnostic and Therapeutic Procedures: An Update
Pediatrics, December 1, 2006; 118(6): 2587 - 2602.
[Abstract] [Full Text] [PDF]

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L. C. Heistein, C. Ramaciotti, W. A. Scott, M. Coursey, P. W. Sheeran, and M. S. Lemler
Chloral Hydrate Sedation for Pediatric Echocardiography: Physiologic Responses, Adverse Events, and Risk Factors
Pediatrics, March 1, 2006; 117(3): e434 - e441.
[Abstract] [Full Text] [PDF]