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Antipyretic Effects of Dipyrone Versus Ibuprofen Versus Acetaminophen in Children: Results of a Multinational, Randomized, Modified Double-Blind Study

Hospital de Clínicas, University of São Paulo, Brazil; Children's Institute, Department of Medicine, University of São Paulo, Av. Dr. Eneas Carvalho de Aguiar 647, 05403-900, São no consensus on whether fever, Paulo, Brazil

Andres Sibbald, MD

Hospital Britânico, Argentina

Fernando Ferrero, MD

Hospital de Niños "Pedro Elizalde," Argentina

Mauricio Plager, MD

Hospital de Niños "Ricardo Gutierrez," Argentina

Maria Elena Santolaya, MD

Hospital Luis Calvo Mackenna, Chile

Anna Maria Escobar, MD

Hospital de Clínicas, University of São Paulo, Brazil

Sandra Campos, MD

Hospital São Paulo, Brazil

Sergio Barragán, MD

Hospital Regional "Lic. Adolfo Lápez Mateos," Mexico

Maximiliano De León González, MD

Hospital Juarez de Mexico, Mexico

Gustavo Lf Kesselring, MD

Aventis Pharma, Brazil

Fever Pediatric Study Group

This study compared the antipyretic effectiveness of acetaminophen, ibuprofen, and dipyrone in young children with fever. The results were based on a modified double-blind, randomized, multinational trial that evaluated 628 febrile children, aged 6 months to 6 year. All three drugs lowered temperature in the 555 patients completing the study. Temperature normalization rates in the ibuprofen and dipyrone groups (78% and 82%, respectively) were significantly higher than the acetaminophen group (68%, P=0.004). After 4 to 6 hours, mean temperature in the dipyrone group was significantly lower than the other groups, demonstrating longer temperature normalization with dipyrone. All three drugs showed comparable tolerability profiles.

Clinical Pediatrics, Vol. 40, No. 6, 313-324 (2001)
DOI: 10.1177/000992280104000602


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