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Clinical Pediatrics
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Serum Homocysteine and Lipoprotein (a) Concentrations in Hypercholesterolemic and Normocholesterolemic Children

T. Laskowska-Klita, PhD

E. Szymczak, MD

Department of Biochemistry, Research National Institute of Mother and Child, Warsaw, Poland

B. Radomyska, PhD

Department of Pediatrics, Research National Institute of Mother and Child, Warsaw, Poland

The relationship between lipids, lipoproteins, total homocysteine, and lipoprotein (a) was studied in hypercholesterolemic and normocholesterolemic children. In hypercholesterolemic children, concentrations of total cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein B, and triglycerides were significantly higher compared to levels in controls, whereas concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I were lower compared to those in the control group. Total serum homocysteine concentrations in children with a positive family history for cardiovascular disease CHD (+) (7.28 pmol/L) were significantly higher than those in the control group (5.45 pmol/L), and in the group of CHD(-) children (5.25 pmol/L). The median value of lipoprotein (a) in patients was 31.5 mg/dL (range, 11-209 mg/dL) and in the control group, 19 mg/dL (range, 11-95 mg/dL). Concentrations of Lp (a), exceeding 30 mg/dL, were present in 45% of CHD (+) children, in 29% of CHD (-) children, and in only 11% of the control group.

Clinical Pediatrics, Vol. 40, No. 3, 149-154 (2001)
DOI: 10.1177/000992280104000304
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