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Reviews

The Utility of Skin Biopsies in Pediatric Cancer Patients: A Single-Institution, Retrospective Review

Eric C. Walter, BS

University of Washington School of Medicine, Seattle, WA

Douglas S. Hawkins, MD

Division of Hematology/Oncology, Department of Pediatrics, Seattle, WA; University of Washington School of Medicine,Seattle, WA; Children's Hospital and Regional Medical Center, MS: CH-29, 4800 Sand Point Way, Seattle, WA 98105-0371

Medical records of all patients who were diagnosed with a malignancy and who underwent a skin biopsy were reviewed to determine the clinical utility of skin biopsies in this population. Skin biopsies resulted in a change or refinement of the prebiopsy diagnosis in 44% of patients undergoing an initial evaluation for a malignancy, 57% of patients on therapy, and 17% of patients off therapy. Skin biopsies led to a change in therapy in 26%, 34%, and 17% of each respective group. Overall, the skin biopsy changed or refined the prebiopsy diagnosis in 45% of cases and altered therapy in 38%. Skin biopsy is a clinically useful tool in pediatric oncology patients for the evaluation of cutaneous findings that elude diagnosis by visual inspection.

Clinical Pediatrics, Vol. 40, No. 3, 139-147 (2001)
DOI: 10.1177/000992280104000303
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