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Adolescents with ASCUS: Are They a High Risk Group?

Dana S. Schmidt, MD

Department of Pediatrics, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio

Ann E. Rader, MD

Fadi Abdul-Karim, MD

Department of Pathology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio

Rina Lazebnik, MD

Department of Pediatrics, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio

Population demographics, risk behaviors, and compliance rates for the management of an ASCUS (atypical squamous cells of undetermined significance) diagnosis are not well studied in the adolescent population. From June 1994 to December 1996, 1175 Papanicalou (pap) smears were performed in an urban adolescent clinic on patients age 12 to 18. Of these, 124 (10.5%) were diagnosed with ASCUS or ASCUS with a qualifying statement. A retrospective chart review (n=83) and telephone interview was performed on patients with ASCUS. Ninety-nine percent of enrollees were African American. Comparisons were made between those patients with normal pap smears and those with ASCUS. No statistically significant difference existed pertaining to age at pap smear, age at menarche, age at first coitus, and education level. A positive association was found in the ASCUS group for the presence of sexually transmitted diseases (P<0.001), number of sexual partners (P<0.0007), and pregnancy (P<0.001). Of the 80% of patients who had an ASCUS diagnosis and were referred for colposcopy (n=62), only 61% attended their appointment (n=38). Thirty-nine percent of these patients were aware of an abnormal diagnosis after colposcopy. For those that attended colposcopy, 56% were accompanied by a parent. For those who were not compliant with attendance, none cited parental consent for the procedure as a barrier to obtaining treatment. Adolescent females in an urban setting with multiple sexual partners, history of sexually transmitted diseases, and prior pregnancy are at a greater risk for ASCUS on cervicovaginal smear when compared to their age-matched controls. In addition, the adolescent compliance rate for colposcopy is low. We, therefore, recommend that these adolescent females be observed diligently.

Clinical Pediatrics, Vol. 40, No. 3, 133-138 (2001)
DOI: 10.1177/000992280104000302


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