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Clinical Pediatrics
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Daily Multivitamins with Iron to Prevent Anemia in Infancy: A Randomized Clinical Trial

Paul L. Geltman, MD

Division of Community, Boston University School of Medicine and Boston Medical Center, Boston, MA; Whittier Street Health Center, 1125 Tremont Street, Roxbury, MA 02120.

Alan F. Meyers, MD

Howard Bauchner, MD

Division of General Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, MA

This study assessed the effectiveness of multivitamins (MV) with iron as prophylaxis against iron deficiency (ID) and anemia in infancy. The study was a double-blind, randomized trial at 2 urban primary care clinics. Subjects included healthy, full-term infants enrolled at their 6-month well-child visit. Parents administered MV, either with iron or without iron, by mouth daily for 3 months. At 9 months of age, 28.3% of 310 had either anemia or ID without anemia. Among infants with any adherence, anemia was found in 11.1% of the iron group and 21.7% in the noniron group (RR=0.5, 95% CI=0.3-1.0). Iron deficiency without anemia was found in 18.5% of the iron group; 14.4% of the noniron group (p=0.46). When administered daily starting at age 6 months, standard-dose multivitamins with iron appear to reduce anemia prevalence at 9 months of age.

Clinical Pediatrics, Vol. 40, No. 10, 549-554 (2001)
DOI: 10.1177/000992280104001003
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