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Prednisolone Plus Albuterol Versus Albuterol Alone in Mild to Moderate Bronchiolitis

Department of Pediatrics, University of South Alabama, Mobile, AL; Department of Pediatrics, University of Kentucky, Room J460, Kentucky Clinic, Lexington, KY 40536-0284

Benjamin Estrada, MD

Jorge Quinonez, MD

Noorkarim Nagji, MD

David Sanford, MD

Robert C. Boerth, MD, PhD

Department of Pediatrics, University of South Alabama, Mobile, AL

To evaluate combination therapy of mild to moderate bronchiolitis with bronchiodilators and corticosteroids, we treated 51 young children with first-time wheezing and symptoms of respiratory tract infection with albuterol plus either prednisolone or placebo for 5 days. Disease severity was scored on days 0, 2, 3, and 6. On day 2, prednisolone resulted in significantly lower scores (2.7 ±1.4 vs. 4.0 ±1.5 in all patients evaluated, p<0.05) than placebo, whereas there was no detectable difference on day 6, suggesting that addition of prednisolone to albuterol transiently accelerates recovery from bronchiolitis. The clinical significance of this effect needs to be evaluated in further studies.

Clinical Pediatrics, Vol. 39, No. 4, 213-220 (2000)
DOI: 10.1177/000992280003900404


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