This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Goebel, J. Articles by Boerth, R. C. Search for Related Content PubMed PubMed Citation Articles by Goebel, J. Articles by Boerth, R. C. Social Bookmarking                   What's this?

Prednisolone Plus Albuterol Versus Albuterol Alone in Mild to Moderate Bronchiolitis

Department of Pediatrics, University of South Alabama, Mobile, AL; Department of Pediatrics, University of Kentucky, Room J460, Kentucky Clinic, Lexington, KY 40536-0284

Benjamin Estrada, MD

Jorge Quinonez, MD

Noorkarim Nagji, MD

David Sanford, MD

Robert C. Boerth, MD, PhD

Department of Pediatrics, University of South Alabama, Mobile, AL

To evaluate combination therapy of mild to moderate bronchiolitis with bronchiodilators and corticosteroids, we treated 51 young children with first-time wheezing and symptoms of respiratory tract infection with albuterol plus either prednisolone or placebo for 5 days. Disease severity was scored on days 0, 2, 3, and 6. On day 2, prednisolone resulted in significantly lower scores (2.7 ±1.4 vs. 4.0 ±1.5 in all patients evaluated, p<0.05) than placebo, whereas there was no detectable difference on day 6, suggesting that addition of prednisolone to albuterol transiently accelerates recovery from bronchiolitis. The clinical significance of this effect needs to be evaluated in further studies.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. McGee and J. Hirschmann Use of Corticosteroids in Treating Infectious Diseases Arch Intern Med, May 26, 2008; 168(10): 1034 - 1046. [Abstract] [Full Text] [PDF]

				H. M. Corneli, J. J. Zorc, P. Mahajan, K. N. Shaw, R. Holubkov, S. D. Reeves, R. M. Ruddy, B. Malik, K. A. Nelson, J. S. Bregstein, et al. A Multicenter, Randomized, Controlled Trial of Dexamethasone for Bronchiolitis N. Engl. J. Med., July 26, 2007; 357(4): 331 - 339. [Abstract] [Full Text] [PDF]

				P. C. Gotzsche, A. Hrobjartsson, K. Maric, and B. Tendal Data Extraction Errors in Meta-analyses That Use Standardized Mean Differences JAMA, July 25, 2007; 298(4): 430 - 437. [Abstract] [Full Text] [PDF]

				A. S. Lieberthal High-Dose Systemic Corticosteroids May Be Effective Early in the Course of Bronchiolitis: In Reply Pediatrics, April 1, 2007; 119(4): 865 - 866. [Full Text] [PDF]

				M. M. Weinberger High-Dose Systemic Corticosteroids May Be Effective Early in the Course of Bronchiolitis Pediatrics, April 1, 2007; 119(4): 864 - 865. [Full Text] [PDF]

				Subcommittee on Diagnosis and Management of Bronch Diagnosis and Management of Bronchiolitis Pediatrics, October 1, 2006; 118(4): 1774 - 1793. [Abstract] [Full Text] [PDF]

				V. J. King, M. Viswanathan, W. C. Bordley, A. M. Jackman, S. F. Sutton, K. N. Lohr, and T. S. Carey Pharmacologic Treatment of Bronchiolitis in Infants and Children: A Systematic Review Arch Pediatr Adolesc Med, February 1, 2004; 158(2): 127 - 137. [Abstract] [Full Text] [PDF]

				J B M van Woensel, W M C van Aalderen, W de Weerd, N J G Jansen, J P J van Gestel, D G Markhorst, A J van Vught, A P Bos, and J L L Kimpen Dexamethasone for treatment of patients mechanically ventilated for lower respiratory tract infection caused by respiratory syncytial virus Thorax, May 1, 2003; 58(5): 383 - 387. [Abstract] [Full Text] [PDF]

				H. Narchi Combination Therapy in Mild to Moderate Bronchiolitis Clinical Pediatrics, October 1, 2000; 39(10): 624 - 624. [PDF]