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Clinical Pediatrics, Vol. 39, No. 4, 203-208 (2000)
DOI: 10.1177/000992280003900402

Detection of Enteroviruses in the Cerebrospinal Fluid by Polymerase Chain Reaction: Prospective Study of Impact on the Management of Hospitalized Children

Virginie Masserey Spicher, MD

Pierre-Yves Berclaz, MD

Department of Pediatrics, University Hospital, Geneva, Switzerland

Jean-Jacques Cheseaux, MD

Laboratory of Virology, University Hospital, Geneva, Switzerland

Pierre-Alain Morandi, PhD

Children's Hospital, Lausanne, Switzerland

Susanne Suter, MD

Department of Pediatrics, University Hospital, Geneva, Switzerland

Werner Wunderli, PhD

Children's Hospital, Lausanne, Switzerland

Claire-Anne Siegrist, MD

Department of Pediatrics, University Hospital, Geneva, Switzerland

A polymerase chain reaction kit (AMPLICOR EV®) for the detection of enteroviruses (EV-PCR) in the cerebrospinal fluid (CSF) was evaluated in clinical conditions in a prospective blinded-intention study. Forty-three children (mean age 2.7 years) hospitalized for suspected meningitis or fever of unclear etiology were enrolled. EV-PCR was performed on a daily basis. Results were available in less than 2 days in 72% of cases. EV-PCR was positive in nine (21%) children, including three infants without CSF pleocytosis. Knowing their EV-PCR result would have allowed a saving of 18 hospital days and 12 days of antibiotic therapy. The EV-PCR in the CSF can thus be practically useful for children hospitalized for meningitis or fever if available on-site on a daily basis.


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