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Clinical Pediatrics, Vol. 39, No. 3, 153-159 (2000)
DOI: 10.1177/000992280003900303

The Ketogenic Diet in Refractory Epilepsy: The Experience of Children's Hospital of Pittsburgh

Neelam G. Katyal, MS, RD

Department of Clinical Nutrition, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213

Anita N. Koehler, PhD, RD

Department of Clinical Nutrition, Children's Hospital of Pittsburgh, PA

Bill McGhee, PharmD

Department of Pharmacy, Children's Hospital of Pittsburgh, PA

Catherine M. Foley, MD

Patricia K. Crumrine, MD

Division of Child Neurology, Children's Hospital of Pittsburgh, PA

The ketogenic diet appears to be effective in reducing seizure frequency in patients with epilepsy refractory to antiepileptic drug therapy. Reported seizure frequencies before and after the diet was initiated were obtained for 48 patients started on the ketogenic diet between December 1994 and January 1998 at Children's Hospital of Pittsburgh. The majority of patients (71%) were able to achieve?50% reduction in seizure activity. Of these, more than half (53%) had >90% reduction in seizures after 45 days of diet therapy. Complications included gastrointestinal complaints and infrequent lipid abnormalities. The ketogenic diet appears to be an effective method of treatment for children with epilepsy refractory to drug therapy.


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